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PM concentration declining saves health expenditure in China
《环境科学与工程前沿(英文)》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1690-4
● Monthly hospitalization expenses are sensitive to increases in PM2.5 exposure.
关键词: Air pollution Health expenditure PM2.5 concentration Economic impact Heterogeneous effect
Mechanism of insulin resistance in obesity: a role of ATP
《医学前沿(英文)》 2021年 第15卷 第3期 页码 372-382 doi: 10.1007/s11684-021-0862-5
关键词: type 2 diabetes energy expenditure mitochondria hyperinsulinemia hyperglucagonemia AMPK
Mechanisms of insulin resistance in obesity
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《医学前沿(英文)》 2013年 第7卷 第1期 页码 14-24 doi: 10.1007/s11684-013-0262-6
Obesity increases the risk for type 2 diabetes through induction of insulin resistance. Treatment of type 2 diabetes has been limited by little translational knowledge of insulin resistance although there have been several well-documented hypotheses for insulin resistance. In those hypotheses, inflammation, mitochondrial dysfunction, hyperinsulinemia and lipotoxicity have been the major concepts and have received a lot of attention. Oxidative stress, endoplasmic reticulum (ER) stress, genetic background, aging, fatty liver, hypoxia and lipodystrophy are active subjects in the study of these concepts. However, none of those concepts or views has led to an effective therapy for type 2 diabetes. The reason is that, there has been no consensus for a unifying mechanism of insulin resistance. In this review article, literature is critically analyzed and reinterpreted for a new energy-based concept of insulin resistance, in which insulin resistance is a result of energy surplus in cells. The energy surplus signal is mediated by ATP and sensed by adenosine monophosphate-activated protein kinase (AMPK) signaling pathway. Decreasing ATP level by suppression of production or stimulation of utilization is a promising approach in the treatment of insulin resistance. In support, many of existing insulin sensitizing medicines inhibit ATP production in mitochondria. The effective therapies such as weight loss, exercise, and caloric restriction all reduce ATP in insulin sensitive cells. This new concept provides a unifying cellular and molecular mechanism of insulin resistance in obesity, which may apply to insulin resistance in aging and lipodystrophy.
关键词: type 2 diabetes energy expenditure inflammation lipotoxicity mitochondria hyperinsulinemia adenosine monophosphate-activated protein kinase (AMPK)
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《医学前沿(英文)》 2015年 第9卷 第2期 页码 139-145 doi: 10.1007/s11684-015-0377-z
In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissue function. Although this view is supported by a large body of literature, it has been challenged by growing evidence that pro-inflammatory cytokines may favor insulin sensitivity through induction of energy expenditure. In this review article, interleukin 15 (IL-15) is used as a new example to explain the beneficial effects of the pro-inflammatory cytokines. IL-15 is secreted by multiple types of cells including macrophages, neutrophils and skeletal muscle cells. IL-15 expression is induced in immune cells by endotoxin and in muscle cells by physical exercise. Its transcription is induced by transcription factor NF-κB. IL-15 binds to its receptor that contains three different subunits (α, β and γ) to activate JAK/STAT, PI3K/Akt, IKK/NF-κB and JNK/AP1 pathways in cells. In the regulation of metabolism, IL-15 reduces weight gain without inhibiting food intake in rodents. IL-15 suppresses lipogenesis, stimulates brown fat function, improves insulin sensitivity through weight loss and energy expenditure. In human, circulating IL-15 is negatively associated with body weight. In the immune system, IL-15 stimulates proliferation and differentiation of T cells, NK cells, monocytes and neutrophils. In the anti-obesity effects of IL-15, T cells and NK cells are not required, but leptin receptor is required. In summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance energy expenditure to protect the body from obesity and type 2 diabetes. The mechanism of IL-15 action remains to be fully uncovered in the regulation of energy expenditure.
关键词: inflammation obesity cytokine energy expenditure insulin resistance
Primary health care for all by 2020: The systematic reform of the medical and health system in China
《医学前沿(英文)》 2010年 第4卷 第1期 页码 3-7 doi: 10.1007/s11684-010-0024-7
Kan ZHANG MM, Wei DONG MM, Ying-Yao CHEN MD,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 134-138 doi: 10.1007/s11684-010-0041-6
关键词: community health general practitioners health management
《环境科学与工程前沿(英文)》 2022年 第16卷 第4期 doi: 10.1007/s11783-021-1475-6
• The concentrations of 13 heavy metals in Taihu Lake were analyzed.
关键词: Heavy metals Human health ambient water quality criteria Taihu Lake Health risk assessment Contribution rate
Percolation-based health management of complex traffic systems
《工程管理前沿(英文)》 2021年 第8卷 第4期 页码 557-571 doi: 10.1007/s42524-021-0174-0
关键词: traffic health health management critical infrastructure systems science and engineering
Structural health monitoring with fiber optic sensors
F. ANSARI
《机械工程前沿(英文)》 2009年 第4卷 第2期 页码 103-110 doi: 10.1007/s11465-009-0032-y
关键词: Bridges structural health monitoring smart skins cracks strains displacements fiber optic sensors FBG structures
Temporal variation of PM-associated health effects in Shijiazhuang, Hebei
《环境科学与工程前沿(英文)》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1376-0
•Annual mean PM2.5 in Shijiazhuang were 87, 95, and 82 µg/m3 in 2015–2017.
关键词: PM2.5 Health effects Integrated exposure-response model Shijiazhuang
《环境科学与工程前沿(英文)》 2023年 第17卷 第11期 doi: 10.1007/s11783-023-1742-9
● A fine portrayal of organic pollutants in a retired industrial park is provided.
关键词: Organic pollutants Retired industrial park Spatial correlation Health risk assessment
Individualized medicine, health medicine, and constitutional theory in Chinese medicine
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《医学前沿(英文)》 2012年 第6卷 第1期 页码 1-7 doi: 10.1007/s11684-012-0173-y
The patterns of modern science and changes in the medical model can result in the transformation of the current state of individualized and health medicines into being the primary trend in medical development. Chinese and Western medical systems are dissimilar in terms of value orientations, thinking style, and research directions because of their different historical and cultural backgrounds. Individualized treatment in modern medicine is mainly established based on individual genome information and the differences in mononucleotide polymorphi-sms. However, such treatment method is expensive, creates an uncertain genetic marker, and leads to different result interpretations, among other problems. The Chinese constitutional theory developed in the 1970s expresses the principle behind Chinese health medicine and individual treatment and provides the corresponding methods. The Chinese constitutional theory divides the constitution of the Chinese population into nine categories based on established classification criteria. It promotes the study of the relationship of each constitution to diseases and Chinese medicine preparation toward adjusting the constitution and preventing diseases. The theory also provides methods and tools for individualized treatment. Constitution identification shows the direction and provides the core technology for the evaluation of the health status. By combining the developments in modern biotechnology, new diagnostic techniques and treatment models of constitution-differentiation, disease-differentiation, and syndrome-differentiation can be established for the development of individualized Chinese medicine treatment and health medicine for the international medical community.
关键词: individualized medicine health medicine constitutional theory in Chinese medicine
Effective interventions on health effects of Chinese rural elderly under heat exposure
《环境科学与工程前沿(英文)》 2022年 第16卷 第5期 doi: 10.1007/s11783-022-1545-4
● Education and subsidy were effective interventions during short-term heat exposure.
关键词: High temperature Health effect Comprehensive evaluation Intervention Rural elderly
E-waste environmental contamination and harm to public health in China
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《医学前沿(英文)》 2015年 第9卷 第2期 页码 220-228 doi: 10.1007/s11684-015-0391-1
The adverse effects of electronic waste (e-waste) on the human body have stirred up concern in recent years. China is one of the countries that confront serious pollution and human exposure of e-waste, and the majority of the population is exposed to potentially hazardous substances that are derived from informal e-waste recycling processes. This study reviews recent reports on human exposure to e-waste in China, with particular focus on exposure routes (e.g., inhalation and ingestion) and several toxicities of human (e.g., endocrine system, respiratory system, reproductive system, developmental toxicity, neurotoxicity, and genetic toxicity). Pieces of evidence that associate e-waste exposure with human health effects in China are assessed. The role of toxic heavy metals (e.g., lead, cadmium, chromium, mercury, and nickel) and organic pollutants (e.g., polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyl (PCBs), polycyclic aromatic hydrocarbons (PAHs), polybrominated biphenyls (PBBs), polyhalogenated aromatic hydrocarbons (PHAHs), bisphenol A (BPA)) on human health is also briefly discussed.
关键词: e-waste heavy metal organic pollutant hazardous toxicity human health China
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《医学前沿(英文)》 2012年 第6卷 第1期 页码 79-84 doi: 10.1007/s11684-012-0179-5
With China’s great efforts to improve public health insurance, clear progress has been achieved toward the ambitious full health insurance coverage strategy for all. The current health insurance schemes in China fall into three categories: urban employee basic health insurance scheme, urban resident scheme, and new rural cooperative medical system. Despite their phasic success, these substantially identity-based, district-varied health insurance schemes have separate operation mechanisms, various administrative institutions, and consequently poor connections. On the other hand, the establishment and implementation of various health insurance schemes provide the preconditioning of more sophisticated social health insurance schemes, the increase in the income of urban and rural people, and the great importance attached by the government. Moreover, the reform of the “Hukou” (household register) system provides economical, official, and institutional bases. Therefore, the establishment of an urban-rural integrated, citizen-based, and nationwide-universal health insurance scheme by the government is critically important to attain equality and national connection. Accordingly, the differences between urban and rural areas should be minimized. In addition, the current schemes, administrative institutions, and networks should be integrated and interconnected. Moreover, more expenditure on health insurance might be essential for the integration despite the settings of global financial crisis. Regardless of the possible challenges in implementation, the proposed new scheme is promising and may be applied in the near future for the benefit of the Chinese people and global health.
关键词: health insurance urban employee basic health insurance scheme urban-resident scheme new rural cooperative medical system
标题 作者 时间 类型 操作
Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes
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期刊论文
Primary health care for all by 2020: The systematic reform of the medical and health system in China
期刊论文
The next step of community health construction: Training general practitioners and implementing health
Kan ZHANG MM, Wei DONG MM, Ying-Yao CHEN MD,
期刊论文
Human health ambient water quality criteria for 13 heavy metals and health risk assessment in Taihu Lake
期刊论文
Multimedia distribution and health risk assessment of typical organic pollutants in a retired industrial
期刊论文